Hydrochloric Acid → HCID 22273511, compound

Participants

Reaction Steps

4M Hydrogen chloride in dioxane (10 ml) was added to a solution of 3-[2-(t-butoxycarbonylamino)ethoxy]-1,2,5-thiadiazole (Method 76; 1.17 g, 4.74 mmol) in dioxane (20 ml) and the mixture was stirred at ambient temperature for 2 days. The resulting solid was collected by filtration, washed with ether and dried to give the title compound (803 mg, 93%) as a white solid NMR 3.20 (m, 2H), 4.58 (t, 2H), 8.36 (m, 4H); m/z 146.

Provenance & Evidence