Hydrochloric Acid → HCID 22273511, compound

HRID 2375292Notes

Reaction equation

HRID 2375292 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][CH2:11][O:12][C:13]1[CH:17]=[N:16][S:15][N:14]=1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[NH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:17]=[N:16][S:15][N:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69310397HCID 69310397, compound

Product 1

HCID 22273511HCID 22273511, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

4M Hydrogen chloride in dioxane (10 ml) was added to a solution of 3-[2-(t-butoxycarbonylamino)ethoxy]-1,2,5-thiadiazole (Method 76; 1.17 g, 4.74 mmol) in dioxane (20 ml) and the mixture was stirred at ambient temperature for 2 days. The resulting solid was collected by filtration, washed with ether and dried to give the title compound (803 mg, 93%) as a white solid NMR 3.20 (m, 2H), 4.58 (t, 2H), 8.36 (m, 4H); m/z 146.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-c286cf00abe0490ea785b524281b2d79
Source dataset
uspto-grants-2008_12
Patent number
US07465728B2

Reaction notes

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