Sulfuric Acid → HCID 85988014, compound

HRID 2375353Notes

Reaction equation

HRID 2375353 reaction equation
S(=O)(=O)(O)O.C[O:7][CH:8](OC)[CH2:9][CH2:10][CH2:11][S:12][C:13]1[N:17]([CH3:18])[C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[N:15][N:14]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH3:18][N:17]1[C:16]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[N:15][N:14]=[C:13]1[S:12][CH2:11][CH2:10][CH2:9][CH:8]=[O:7]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 69152601HCID 69152601, compound

Product 1

HCID 85988014HCID 85988014, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

Concentrated sulfuric acid was added to a solution of 3-[(4,4-dimethoxybutyl)thio]-4-methyl-5-phenyl-4H-1,2,4-triazole (20.49 mmol, 6.30 g) in ethanol (50 ml) until cloudy. The mixture was stirred at 40° C. for 2 h and then made alkaline with sodium carbonate and subsequently extracted with ethyl acetate. The organic phase was dried and concentrated, resulting in 4.8 g of the title compound colorless oil.

Workup

  1. extractionsubsequently extracted with ethyl acetate
  2. customThe organic phase was dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-7b71c97eadb9416c98eadb771b392295
Source dataset
uspto-grants-2008_12
Patent number
US07465744B2

Reaction notes

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