HCID 10404056, compound → HCID 10314122, compound

HRID 2375422Notes

Reaction equation

HRID 2375422 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:18]([CH3:19])=[C:17]3[C:12]([C:13]([CH3:21])=[N:14][N:15]=[C:16]3[CH3:20])=[C:11]2[CH3:22])=[CH:6][C:5]=1[CH2:23][OH:24])[CH3:2]>O=[Mn]=O>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:11]([CH3:22])=[C:12]3[C:17]([C:16]([CH3:20])=[N:15][N:14]=[C:13]3[CH3:21])=[C:18]2[CH3:19])=[CH:6][C:5]=1[CH:23]=[O:24])[CH3:2]

Participants

3

Reactant 1

HCID 10404056HCID 10404056, compound

Product 1

HCID 10314122HCID 10314122, compound

Reagents, catalysts & solvents 1

HCID 14801Manganese dioxideCatalyst

Procedure

Utilizing the general procedure outlined in Example 82, [5-ethoxy-2-(1,4,5,7-tetramethyl-pyrrolo[3,4-d]pyridazin-6-yl)-phenyl]-methanol (prepared as described in Example 81; 100 mg, 0.3 mmol) reacted with MnO2 (200 mg, excess) to afford 2-ethoxy-5-(1,4,5,7-tetramethyl-pyrrolo[3,4-d]pyridazin-6-yl)-benzaldehyde as a yellow solid: 1H NMR (CDCl3, 500 MHz) δ 9.20 (s, 1H), 7.57 (s, 1H), 7.34 (d, 1H), 7.24 (d, 1H), 4.20 (q, 2H), 2.90 (s, 6H), 2.42 (s, 6H), 1.51 (t, 3H); MS (ESI) 324 (M+H)+.

Sources & evidence

ORD record
ord-28188f860d4c4efe9328d03b6990b466
Source dataset
uspto-grants-2008_12
Patent number
US07465730B2

Reaction notes

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