HCID 10404056, compound → HCID 10314122, compound

Participants

Reaction Steps

Utilizing the general procedure outlined in Example 82, [5-ethoxy-2-(1,4,5,7-tetramethyl-pyrrolo[3,4-d]pyridazin-6-yl)-phenyl]-methanol (prepared as described in Example 81; 100 mg, 0.3 mmol) reacted with MnO2 (200 mg, excess) to afford 2-ethoxy-5-(1,4,5,7-tetramethyl-pyrrolo[3,4-d]pyridazin-6-yl)-benzaldehyde as a yellow solid: 1H NMR (CDCl3, 500 MHz) δ 9.20 (s, 1H), 7.57 (s, 1H), 7.34 (d, 1H), 7.24 (d, 1H), 4.20 (q, 2H), 2.90 (s, 6H), 2.42 (s, 6H), 1.51 (t, 3H); MS (ESI) 324 (M+H)+.

Provenance & Evidence