Letrozole → HCID 178509721, compound

HRID 2375437Notes

Reaction equation

HRID 2375437 reaction equation
C1C(C#N)=CC=[C:3]([CH:9](N2N=CN=C2)[C:10]2[CH:11]=[CH:12][C:13]([C:16]#[N:17])=[CH:14][CH:15]=2)C=1.BrCC1C=CC(C#N)=CC=1.[NH:33]1[CH:37]=[N:36]C=[N:34]1>>[NH:33]1[CH:37]=[N:36][C:3]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)=[N:34]1

Participants

4

Reactant 3

HCID 3902LetrozoleHCID 92571H-1,2,4-TriazoleHCID 869964-(Bromomethyl)benzonitrile

Product 1

HCID 178509721HCID 178509721, compound

Procedure

U.S. Pat. No. 4,978,672 (“the '672 patent”) describes a process for preparing letrozole by reacting α-bromo-4-tolunitrile with 1,2,4-triazole to produce 4-[1-(1,2,4-triazolyl)methyl]-benzonitrile, and reacting the product with 4-fluorobenzonitrile to obtain letrozole.

Sources & evidence

ORD record
ord-d56ff973e540456698f251da68a7db30
Source dataset
uspto-grants-2008_12
Patent number
US07465749B2

Reaction notes

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