(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate → HCID 86697229, compound

HRID 237567Notes

Reaction equation

HRID 237567 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]2[C:10]=1[C@@H:9](O)CC2.O[C:19]1C=CC2[C@H](CC(OC)=O)COC=2C=1.Br[C:34]1[CH:42]=[CH:41][C:40]([F:43])=[C:39]2[C:35]=1[CH2:36][CH2:37][C@H:38]2[O:44][C:45]1[CH:58]=[CH:57][C:48]2[C@H:49]([CH2:52][C:53]([O:55][CH3:56])=[O:54])[CH2:50][O:51][C:47]=2[CH:46]=1>>[CH3:19][C:3]1[CH:4]=[C:5]([CH:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)[CH:6]=[C:10]([CH3:9])[C:2]=1[C:34]1[CH:42]=[CH:41][C:40]([F:43])=[C:39]2[C:35]=1[CH2:36][CH2:37][C@H:38]2[O:44][C:45]1[CH:58]=[CH:57][C:48]2[C@H:49]([CH2:52][C:53]([O:55][CH3:56])=[O:54])[CH2:50][O:51][C:47]=2[CH:46]=1

Participants

4

Reactant 3

HCID 53393313(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetateHCID 86697103{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697228HCID 86697228, compound

Product 1

HCID 86697229HCID 86697229, compound

Procedure

The title compound is prepared from (S)-7-fluoro-4-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-inden-1-ol and (S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate following a procedure analogous to that described in Step 3 of Intermediate 1. LC (method 26): tR=0.95 min; Mass spectrum (ESI+): m/z=531 [M+H]+.

Sources & evidence

ORD record
ord-ac947d436c5a4ea69bd40e0f2df14a8c
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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