(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate → HCID 86697230, compound

HRID 237568Notes

Reaction equation

HRID 237568 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([C:12]2[CH2:17][CH2:16][O:15][C:14](=[O:18])[CH:13]=2)=[C:6]2[C:10]=1[C@@H:9](O)CC2.O[C:20]1C=CC2[C@H](CC(OC)=O)COC=2C=1.Br[C:35]1[CH:43]=[CH:42][C:41]([F:44])=[C:40]2[C:36]=1[CH2:37][CH2:38][C@H:39]2[O:45][C:46]1[CH:59]=[CH:58][C:49]2[C@H:50]([CH2:53][C:54]([O:56][CH3:57])=[O:55])[CH2:51][O:52][C:48]=2[CH:47]=1>>[CH3:20][C:3]1[CH:4]=[C:5]([C:12]2[CH2:17][CH2:16][O:15][C:14](=[O:18])[CH:13]=2)[CH:6]=[C:10]([CH3:9])[C:2]=1[C:35]1[CH:43]=[CH:42][C:41]([F:44])=[C:40]2[C:36]=1[CH2:37][CH2:38][C@H:39]2[O:45][C:46]1[CH:59]=[CH:58][C:49]2[C@H:50]([CH2:53][C:54]([O:56][CH3:57])=[O:55])[CH2:51][O:52][C:48]=2[CH:47]=1

Participants

4

Reactant 3

HCID 53393313(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetateHCID 86697103{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697231HCID 86697231, compound

Product 1

HCID 86697230HCID 86697230, compound

Procedure

The title compound is prepared from (S)-4-(7-fluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl)-5,6-dihydro-2H-pyran-2-one and (S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate following a procedure analogous to that described in Step 3 of Intermediate 1. LC (method 7): tR=1.18 min; Mass spectrum (ESI+): m/z=543 [M+H]+.

Sources & evidence

ORD record
ord-125d2efc55bf4a568d30a2604712632e
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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