Ethanol → (-)-Salbutamol

Participants

Reaction Steps

In a 25 ml reactor equipped with a condenser, thermometer, and mechanical stirrer loaded at room temperature levalbuterol HCl (1.2 g) and absolute ethanol (15 ml). The solution was warmed to 45° C. to 50° to obtain a solution. The solution was cooled to room temperature and after MTBE (8.75 ml) was added. The solution was stirred at 15° C. for 2 hours to obtain a suspension. The solid was collected by filtration and washed with MTBE (3 ml) to obtain levalbuterol Polymorph A (0.8 g).

Provenance & Evidence