反应详情

In a 25 ml reactor equipped with a condenser, thermometer, and mechanical stirrer loaded at room temperature levalbuterol HCl (1.2 g) and absolute ethanol (15 ml). The solution was warmed to 45° C. to 50° to obtain a solution. The solution was cooled to room temperature and after MTBE (8.75 ml) was added. The solution was stirred at 15° C. for 2 hours to obtain a suspension. The solid was collected by filtration and washed with MTBE (3 ml) to obtain levalbuterol Polymorph A (0.8 g).

1. customIn a 25 ml reactor equipped with a condenser
2. customthermometer, and mechanical stirrer loaded at room temperature
3. temperatureThe solution was warmed to 45° C. to 50°
4. customto obtain a solution
5. customto obtain a suspension
6. filtrationThe solid was collected by filtration
7. washwashed with MTBE (3 ml)