6-Aminobenzothiazole → Benzothiazol-6-yl-(6-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

HRID 2375815Notes

Reaction equation

HRID 2375815 reaction equation
ClC1C2C=C(C3CCN(C(OC(C)(C)C)=O)CC=3)NC=2N=CN=1.Cl[C:25]1[C:26]2[CH:33]=[C:32]([I:34])[NH:31][C:27]=2[N:28]=[CH:29][N:30]=1.[S:35]1[C:39]2[CH:40]=[C:41]([NH2:44])[CH:42]=[CH:43][C:38]=2[N:37]=[CH:36]1>>[S:35]1[C:39]2[CH:40]=[C:41]([NH:44][C:25]3[C:26]4[CH:33]=[C:32]([I:34])[NH:31][C:27]=4[N:28]=[CH:29][N:30]=3)[CH:42]=[CH:43][C:38]=2[N:37]=[CH:36]1

Participants

4

Reactant 3

HCID 682886-AminobenzothiazoleHCID 457897324-Chloro-6-iodo-7H-pyrrolo(2,3-d)pyrimidineHCID 58709797tert-butyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 58710006Benzothiazol-6-yl-(6-iodo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine

Procedure

Following the General method for the reaction of amines with tert-butyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3,6-dihydropyridine-1(2H)-carboxylate to generate compounds of Formula I-B-Boc, but using 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine and benzothiazol-6-ylamine, one obtained the title compound. MS (ES+): m/z 393.88 (100) [MH+].

Sources & evidence

ORD record
ord-c6cbfb68679d48ed8c420bdf5fe4d937
Source dataset
uspto-grants-2008_12
Patent number
US07465726B2

Reaction notes

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