HCID 58710084, compound → HCID 20991136, compound

HRID 2375836Notes

Reaction equation

HRID 2375836 reaction equation
C([O:8][C:9](=[O:20])[C:10]([CH3:19])([CH3:18])[CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:18][C:10]([CH3:19])([CH2:11][N:12]1[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:9]([OH:20])=[O:8]

Participants

4

Reactant 1

HCID 58710084HCID 58710084, compound

Product 1

HCID 20991136HCID 20991136, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of benzyl-2,2-dimethyl-3-piperidin-1-ylpropanoate (117.0 mg, 0.42 mmol) in ethanol (5 mL) was slowly added 10% wt Palladium in carbon (50 mg, 0.05 mmol). The reaction mixture was left to stir at rt for 1 h under hydrogen. The mixture was filtered through Celite and concentrated in vacuo, which afforded the title compound as a yellow solid. 1H NMR (400 MHz, CDCl3): δ=1.22 (s, 6H), 1.28-1.39 (bs, 2H), 1.74-1.79 (m, 4H), 2.76 (s, 2H), 2.79-3.08 (bs, 4H).

Workup

  1. waitThe reaction mixture was left
  2. filtrationThe mixture was filtered through Celite
  3. concentrationconcentrated in vacuo, which

Sources & evidence

ORD record
ord-2b28a7a0e54a44c996481b2bcfe7b5ea
Source dataset
uspto-grants-2008_12
Patent number
US07465726B2

Reaction notes

Loading…