反应详情

A mixture of 6-chloropyrimidin-4(3H)-one (5 g), methyliodide (2.6 mL) and K2CO3 (10.6 g) in acetone (100 mL) is stirred at room temperature over night. The mixture is partitioned between water and ethyl acetate. The organic phase is washed with brine, dried (MgSO4) and concentrated. The residue is triturated with diisopropylether to give the title compound. Yield: 5.1 g; LC (method 11): tR=0.25 min; Mass spectrum (ESI+): m/z=145 [M+H]+.

1. customThe mixture is partitioned between water and ethyl acetate
2. washThe organic phase is washed with brine
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. customThe residue is triturated with diisopropylether