HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237600Generated: October 29, 2026
Ammonium Chloride → 5-(4-Bromo-3,5-dimethylphenyl)-2H-1,2,3,4-tetrazole
https://huagongshe.com/reaction/237600
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-Bromo-3,5-dimethyl-benzonitrile | HCID 11085070 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(4-Bromo-3,5-dimethylphenyl)-2H-1,2,3,4-tetrazole | HCID 86697267 | — |
Reaction Steps
To a solution of 4-bromo-3,5-dimethylbenzonitrile (1 g) in N,N-dimethylformamide (10 mL) is added NH4Cl (770 mg) and NaN3 (800 mg) and the mixture is heated to 100° C. for 12 hours. After cooling to room temperature the mixture is diluted with water. The formed precipitate is filtered off, washed with water and dried to give the title compound. Yield: 650 mg; Mass spectrum (ESI+): m/z=253 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642585B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-2c8a306a698340d7a724d56ee6ababad |
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| Source note | uspto-grants-2014_02 |
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