反应详情

温度

60 °C

A mixture of ethyl (2E)-3-(2-chloro-5-pyrimidinyl)acrylate (200 mg), (3R)-1-benzyl-3-pyrrolidinamine (0.244 mL), and N,N-dimethylformamide (5 mL) was stirred for 3 hours at 60° C. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was washed with saturated NaHCO3 and brine, dried over MgSO4, filtered, and evaporated in vacuo to give ethyl (2E)-3-(2-{[(3R)-1-benzyl-3-pyrrolidinyl]amino}-5-pyrimidinyl)acrylate (330 mg).

1. customThe reaction mixture was partitioned between ethyl acetate and H2O
2. washThe organic layer was washed with saturated NaHCO3 and brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. customevaporated in vacuo