Hydrogen chloride-ethyl acetate → HCID 53256448, compound

HRID 2376085Notes

Reaction equation

HRID 2376085 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@@H:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8]1.[ClH:23].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:23].[ClH:23].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:20]=[CH:21][CH:22]=1)[CH2:6][N:7]1[CH2:11][CH2:10][C@@H:9]([NH2:12])[CH2:8]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 53256447HCID 53256447, compound

Product 1

HCID 53256448HCID 53256448, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of tert-butyl [(3R)-1-(3-methoxybenzyl)-3-pyrrolidinyl]carbamate (739 mg) in ethyl acetate (3.7 mL) was added 4N HCl-ethyl acetate (6.0 mL), which was stirred at room temperature for 1.5 hours. The mixture was concentrated to give (3R)-1-(3-methoxybenzyl)-3-pyrrolidinamine dihydrochloride (702 mg) as a off-white amorphous.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-36f74f7d0bab46c5a6a50d3fc84731ba
Source dataset
uspto-grants-2008_12
Patent number
US07465731B2

Reaction notes

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