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HRID2376117

反应详情

EQUATION

反应方程式

HRID 2376117 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1CC[C@@H](Nc2ncc(CO)cc2Cl)C1
HCID86603728

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CC[C@@H](Nc2ncc(C=O)cc2Cl)C1
HCID86603729

未命名化合物

收率 100.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[O]=[Mn]=[O]
催化剂HCID14801

Manganese oxide (Mn2O4)

MnO2

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A mixture of tert-butyl (3R)-3-{[3-chloro-5-(hydroxymethyl)-2-pyridinyl]amino}-1-pyrrolidinecarboxylate (0.95 g) and MnO2 (3.02 g) in AcOEt (30 ml) was refluxed under stirring for 1.5 hours. After removal of the insoluble material, and the solvent was evaporated in vacuo to give tert-butyl (3R)-3-[(3-chloro-5-formyl-2-pyridinyl)amino]-1-pyrrolidinecarboxylate (0.95 g).

WORKUP

后处理

  1. temperaturewas refluxed
  2. customAfter removal of the insoluble material
  3. customthe solvent was evaporated in vacuo