Hydrochloric Acid → HCID 136335105, compound

HRID 2376185Notes

Reaction equation

HRID 2376185 reaction equation
[CH:1]1([N:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][C:13]3[N:14]=[CH:15][C:16](/[CH:19]=[CH:20]/[C:21]([NH:23][O:24]C4CCCCO4)=[O:22])=[N:17][CH:18]=3)[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:31]>CO>[ClH:31].[ClH:31].[CH:1]1([N:7]2[CH2:11][CH2:10][C@@H:9]([NH:12][C:13]3[N:14]=[CH:15][C:16](/[CH:19]=[CH:20]/[C:21]([NH:23][OH:24])=[O:22])=[N:17][CH:18]=3)[CH2:8]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86603819HCID 86603819, compound

Product 1

HCID 136335105HCID 136335105, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of (2E)-3-(5-{[(3R)-1-cyclohexyl-3-pyrrolidinyl]amino}-2-pyrazinyl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (274 mg) in methanol (6.6 mL) was added hydrogen chloride in methanol (0.659 mL). After stirring at room temperature for 1 hour, the reaction mixture was evaporated in vacuo and triturated with ethyl acetate to give (2E)-3-(5-{[(3R)-1-cyclohexyl-3-pyrrolidinyl]amino}-2-pyrazinyl)-N-hydroxyacrylamide dihydrochloride (252 mg).

Workup

  1. customthe reaction mixture was evaporated in vacuo
  2. customtriturated with ethyl acetate

Sources & evidence

ORD record
ord-c0a531b5252f4326bfadca4333104c33
Source dataset
uspto-grants-2008_12
Patent number
US07465731B2

Reaction notes

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