3-(p-Methoxyphenyl)propionic acid → HCID 23114316, compound

HRID 2376315Notes

Reaction equation

HRID 2376315 reaction equation
[CH3:1][C:2]1([CH3:21])[CH:6]([C:7]2[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=2)[C:5]2[CH:14]=[C:15]([NH2:20])[C:16]([CH3:19])=[C:17]([CH3:18])[C:4]=2[O:3]1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32](O)=[O:33])=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][C:32]([NH:20][C:15]2[C:16]([CH3:19])=[C:17]([CH3:18])[C:4]3[O:3][C:2]([CH3:21])([CH3:1])[CH:6]([C:7]4[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][CH:12]=4)[C:5]=3[CH:14]=2)=[O:33])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 957503-(p-Methoxyphenyl)propionic acidHCID 68707679HCID 68707679, compound

Product 1

HCID 23114316HCID 23114316, compoundYield 64%

Procedure

Using 2,2,6,7-tetramethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-amine obtained Reference Example 139 and 3-(4-methoxyphenyl)propionic acid, the title compound was obtained in the same manner as in Reference Example 359. Yield 64%. Melting point: 149-150° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-a1ca50be822f49a79fd8e5cb309dbc9a
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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