HCID 68711355, compound → HCID 68709946, compound

HRID 2376404Notes

Reaction equation

HRID 2376404 reaction equation
C([NH:8][C:9]1[C:10]([CH3:30])=[C:11]([CH3:29])[C:12]2[O:16][C@@H:15]([CH3:17])[C@@H:14]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=3)[C:13]=2[C:27]=1[CH3:28])C1C=CC=CC=1>CCCCCC>[CH:24]([C:21]1[CH:22]=[CH:23][C:18]([C@H:14]2[C:13]3[C:27]([CH3:28])=[C:9]([NH2:8])[C:10]([CH3:30])=[C:11]([CH3:29])[C:12]=3[O:16][C@H:15]2[CH3:17])=[CH:19][CH:20]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 1

HCID 68711355HCID 68711355, compound

Product 1

HCID 68709946HCID 68709946, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Using (cis)-3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran obtained in Reference Example 349, (cis)-5-bromo-3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran was synthesized in the same manner as in Reference Example 23. Using this compound, (cis)-N-benzyl-3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-amine were synthesized in the same manner as in Reference Example 24. Using this compound, the title compound was synthesized in the same manner as in Reference Example 30. Yield 83%. Melting point: 91-92° C. (hexane).

Workup

  1. customwas synthesized in the same manner as in Reference Example 23
  2. customwere synthesized in the same manner as in Reference Example 24

Sources & evidence

ORD record
ord-02e5f97357c64364a881cd75e9d0d158
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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