Ethyl acetate hexane → HCID 11303984, compound

HRID 2376437Notes

Reaction equation

HRID 2376437 reaction equation
[C:1]([NH:5][C:6]([NH:8][C:9]1[C:10]([CH3:30])=[C:11]([CH2:28]O)[C:12]2[O:16][CH2:15][C@H:14]([C:17]3[CH:22]=[CH:21][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:19][CH:18]=3)[C:13]=2[C:26]=1[CH3:27])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C.CCCCCC>C(Cl)(Cl)Cl>[C:1]([NH:5][C:6]([NH:8][C:9]1[C:10]([CH3:30])=[C:11]([CH3:28])[C:12]2[O:16][CH2:15][C@H:14]([C:17]3[CH:18]=[CH:19][C:20]([CH:23]([CH3:25])[CH3:24])=[CH:21][CH:22]=3)[C:13]=2[C:26]=1[CH3:27])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 68710233HCID 68710233, compound

Product 1

HCID 11303984HCID 11303984, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using (+)-N-(tert-butyl)-N′-((3R)-7-(hydroxymethyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)urea obtained in Example 49, the title compound was synthesized in the same manner as in Example 45. Yield: 57%. Melting point: 209-210° C. (ethyl acetate-hexane). [α]D20=+53.2° (c=0.47, chloroform).

Sources & evidence

ORD record
ord-5141b4d3a3a6457fa57879eb820aed0c
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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