HCID 23114244, compound → HCID 23114233, compound

HRID 2376448Notes

Reaction equation

HRID 2376448 reaction equation
[OH:1][CH:2]([C:5]1[C:13]2[O:12][CH2:11][CH:10]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)[C:9]=2[C:8]([CH3:23])=[C:7]([NH:24][C:25](=[O:31])[CH2:26][C:27]([CH3:30])([CH3:29])[CH3:28])[C:6]=1[CH3:32])[CH2:3][CH3:4]>CCCCCC.C(OCC)(=O)C>[CH:20]([C:17]1[CH:18]=[CH:19][C:14]([CH:10]2[C:9]3[C:8]([CH3:23])=[C:7]([NH:24][C:25](=[O:31])[CH2:26][C:27]([CH3:28])([CH3:30])[CH3:29])[C:6]([CH3:32])=[C:5]([C:2](=[O:1])[CH2:3][CH3:4])[C:13]=3[O:12][CH2:11]2)=[CH:15][CH:16]=1)([CH3:22])[CH3:21]

Participants

3

Reactant 1

HCID 23114244HCID 23114244, compound

Product 1

HCID 23114233HCID 23114233, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using a diastereo mixture of N-(7-(1-hydroxypropyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in the synthesis in Examples 30 and 31, the title compound was synthesized in the same manner as in Example 32. Yield: 18%. Melting point: 163-164° C. (hexane-ethyl acetate).

Workup

  1. customobtained in the synthesis in Examples 30 and 31

Sources & evidence

ORD record
ord-1a669fd0d36e41a9bf4c48b36b9511f9
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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