2-Amino-2-methyl-1-propanol → HCID 23114378, compound

HRID 2376505Notes

Reaction equation

HRID 2376505 reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:28])[NH:6][C:7]1[C:8]([CH3:27])=[C:9]([CH3:26])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25].[NH2:31][C:32]([CH3:36])([CH3:35])[CH2:33][OH:34]>CCCCCC.C(OCC)(=O)C>[OH:34][CH2:33][C:32]([NH:31][C:5]([NH:6][C:7]1[C:8]([CH3:27])=[C:9]([CH3:26])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25])=[O:28])([CH3:36])[CH3:35]

Participants

4

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 86618058HCID 86618058, compound

Product 1

HCID 23114378HCID 23114378, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl(3-(4-isopropylphenyl)-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 138 and 2-amino-2-methyl-1-propanol, the title compound was synthesized in the same manner as in Example 143. Yield: 39%. Melting point: 157-158° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-e45491a74818429aa0744899f0e7bde7
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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