3-Bromo-6-ethylpyridazine → 3-(4-Chloro-3,5-dimethyl-phenyl)-6-ethyl-pyridazine

HRID 237653Notes

Reaction equation

HRID 237653 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Br[C:20]1[N:21]=[N:22][C:23]([CH2:26][CH3:27])=[CH:24][CH:25]=1>>[Cl:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[N:21]=[N:22][C:23]([CH2:26][CH3:27])=[CH:24][CH:25]=2)=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 197973093-Bromo-6-ethylpyridazineHCID 532171282-(4-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 866973263-(4-Chloro-3,5-dimethyl-phenyl)-6-ethyl-pyridazine

Procedure

The title compound is prepared from 2-cloro-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 3-bromo-6-ethyl-pyridazine following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 11): tR=1.00 min; Mass spectrum (ESI+): m/z=247/249 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-1d7b70542c2a422cbde44f2150084c44
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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