3-Amino-1-propanol → HCID 23114232, compound

HRID 2376537Notes

Reaction equation

HRID 2376537 reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:30])[NH:6][C:7]1[C:8]([CH3:29])=[C:9]([C:26](=[O:28])[CH3:27])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25].[OH:33][CH2:34][CH2:35][CH2:36][NH2:37]>>[C:26]([C:9]1[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:16]=[CH:17][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:19][CH:20]=3)[C:11]=2[C:24]([CH3:25])=[C:7]([NH:6][C:5]([NH:37][CH2:36][CH2:35][CH2:34][OH:33])=[O:30])[C:8]=1[CH3:29])(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 86618063HCID 86618063, compound

Product 1

HCID 23114232HCID 23114232, compoundYield 59%

Procedure

Using 2,2,2-trichloroethyl(7-acetyl-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 206 and 3-hydroxypropylamine, the title compound was obtained in the same as manner as in Example 143. Yield: 59%.

Sources & evidence

ORD record
ord-52cf48ab54f94ad999b3fd12299b2ebc
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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