Dimethylamine → HCID 86612367, compound

HRID 2376576Notes

Reaction equation

HRID 2376576 reaction equation
[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH:7](O)[C:6]=2[C:5]([CH3:14])=[C:4]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:3]=1[CH3:23].[CH3:24][NH:25][CH3:26]>C(OCC)(=O)C.CCCCCC>[Br:1][C:2]1[C:10]2[O:9][C:8]([CH3:12])([CH3:11])[CH:7]([N:25]([CH3:26])[CH3:24])[C:6]=2[C:5]([CH3:14])=[C:4]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:3]=1[CH3:23]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 86612364HCID 86612364, compound

Product 1

HCID 86612367HCID 86612367, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using tert-butyl (7-bromo-3-hydroxy-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 236 and dimethylamine, the title compound was synthesized in the same manner as in Example 297. Yield: 89%. Melting point: 111-112° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-56f8d1fc42a9482f8cbeca482dcba247
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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