Morpholine → HCID 58855409, compound

HRID 2376605Notes

Reaction equation

[F:1][C:2]([F:18])([C:9]([F:17])([F:16])[C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])[CH2:3][O:4][CH2:5][CH:6]1[O:8][CH2:7]1.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[O:22]1[CH2:23][CH2:24][N:19]([CH2:7][CH:6]([OH:8])[CH2:5][O:4][CH2:3][C:2]([F:18])([F:1])[C:9]([F:17])([F:16])[C:10]([F:15])([F:14])[CH:11]([F:13])[F:12])[CH2:20][CH2:21]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 27758862-{[(2,2,3,3,4,4,5,5-Octafluoropentyl)oxy]methyl}oxirane

Product 1

HCID 58855409HCID 58855409, compoundYield 89.1%

Conditions

Temperature: 80 °C

Procedure

28.8 g of glycidyl 2,2,3,3,4,4,5,5-octafluoropentyl ether was added dropwise to 8.7 g of morpholine. The mixture was then stirred at 80° C. for 10 hours. The reaction mixture was directly purified by silica gel column chromatography. There was obtained 33.4 g of 1-morpholino-3-(2,2,3,3,4,4,5,5-octafluoropentyloxy)-2-propanol (yield 89%).

Workup

customThe reaction mixture was directly purified by silica gel column chromatography

Sources & evidence

ORD record: ord-2486bcc7ee5744469b72e13b206d08ae
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07468236B2

Reaction notes

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