反应详情

1-Hydroxyimino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one was dissolved in EtOH/NH3 (20:1) and hydrogenated in a bomb using Raney nickel and hydrogen (500 psi/3447 kPa) at 100° C. for 10 hours. The resulting mixture was filtered and concentrated to provide an oil which was purified by silica gel chromatography to yield the title compound.

1. customat 100° C.
2. customfor 10 hours
3. filtrationThe resulting mixture was filtered
4. concentrationconcentrated
5. customto provide an oil which
6. customwas purified by silica gel chromatography