HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Hydroxyimino)-3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 1-Amino-3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Hydroxyimino)-3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one | HCID 71357823 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol, reaction products with ammonia, distn. residues | HCID 22020343 | — |
| Product | 1-Amino-3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one | HCID 21072565 | — |
Reaction Steps
1-Hydroxyimino-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one was dissolved in EtOH/NH3 (20:1) and hydrogenated in a bomb using Raney nickel and hydrogen (500 psi/3447 kPa) at 100° C. for 10 hours. The resulting mixture was filtered and concentrated to provide an oil which was purified by silica gel chromatography to yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468365B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-46fffd3d65494532b916a04015f91c99 |
| Source note | uspto-grants-2008_12 |