Tetrahydrofuran → 2-(4-Bromo-3,5-dimethyl-phenyl)-thiazole

HRID 237662Notes

Reaction equation

HRID 237662 reaction equation
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](I)=[CH:4][C:3]=1[CH3:10].[Br-].[S:12]1[CH:16]=[CH:15][N:14]=[C:13]1[Zn+].O1CCCC1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([C:13]2[S:12][CH:16]=[CH:15][N:14]=2)=[CH:4][C:3]=1[CH3:10]

Participants

6

Reactant 3

HCID 8028TetrahydrofuranHCID 207480372-Bromo-5-iodo-1,3-dimethylbenzeneHCID 178419763HCID 178419763, compound

Product 1

HCID 866973352-(4-Bromo-3,5-dimethyl-phenyl)-thiazole

Reagents, catalysts & solvents 2

HCID 178418397HCID 178418397, compoundCatalystHCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 2-bromo-5-iodo-1,3-dimethyl-benzene (0.28 g), 2-thiazolylzinc bromide (0.5 mol/L in tetrahydrofuran; 1.9 mL), tetrakis(triphenylphosphine)palladium(0) (52 mg), and tetrahydrofuran (5 mL) under argon atmosphere is stirred at 100° C. for 3 h. After cooling to room temperature, water is added and the resulting mixture is extracted with ethyl acetate. The solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate) to give the title compound. LC (method 9): tR=1.19 min; Mass spectrum (ESI+): m/z=268/270 (Br) [M+H]+.

Workup

  1. temperatureAfter cooling to room temperature
  2. extractionthe resulting mixture is extracted with ethyl acetate
  3. customThe solvent is evaporated
  4. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate)

Sources & evidence

ORD record
ord-0a4cc1e8f98b44ab9d96e1a8c60411dc
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

Loading…