HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromotoluene → 1-Benzyl-4-(3-methylphenyl)-4-piperidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromotoluene | HCID 11560 | — |
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Benzyl-4-(3-methylphenyl)-4-piperidinol | HCID 17967024 | — |
Reaction Steps
This compound is prepared by the procedure described in step A of preparation 1.7, from 1.55 g of magnesium in 25 ml of THF, a solution of 11 g of 3-bromotoluene in 15 ml of THF and a solution of 10 g of 1-benzyl-4-piperidone in 30 ml of THF. The product obtained is chromatographed on silica gel, eluting with a DCM/MeOH (97/3; v/v) mixture. This gives 14.5 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468368B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-c617128cc4974fc5ad39c9da4ebb9694 |
| Source note | uspto-grants-2008_12 |