反应详情

A mixture of 13.52 g of tert-butyl 1-piperazinecarboxylate, 10.81 g of 3,6-dichloropyridazine and 20 ml of triethylamine in 100 ml of n-butanol is heated at reflux for 5 hours. It is concentrated under vacuum and the residue is chromatographed on silica gel, eluting with a DCM/AcOEt (90/10; v/v) mixture. This gives 14 g of the expected product, which is used as it is.

1. temperatureis heated
2. temperatureat reflux for 5 hours
3. concentrationIt is concentrated under vacuum
4. customthe residue is chromatographed on silica gel
5. washeluting with a DCM/AcOEt (90/10; v/v) mixture