Hydrochloric Acid → HCID 23106798, compound

HRID 2376664Notes

Reaction equation

HRID 2376664 reaction equation
C([O:4][CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][C:8]=1[Cl:16])(=O)C.Cl>CO>[Cl:16][C:8]1[CH:9]=[C:10]([C:13](=[O:15])[CH3:14])[CH:11]=[CH:12][C:7]=1[CH2:6][CH2:5][OH:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23106776HCID 23106776, compound

Product 1

HCID 23106798HCID 23106798, compoundYield 110%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-(4-Acetyl-2-chlorophenyl)ethyl acetate (4.87 g) was dissolved in methanol (80 ml), and thereto was added concentrated hydrochloric acid (20 ml), followed by refluxing. Four hours later the temperature of the reaction mixture was kept at room temperature, and methanol was removed in vacuo. Then the residue was diluted with ethyl acetate, washed with brine, dried and concentrated to give the object compound (4.42 g).

Workup

  1. temperatureby refluxing
  2. customFour hours
  3. customwas kept at room temperature
  4. custommethanol was removed in vacuo
  5. additionThen the residue was diluted with ethyl acetate
  6. washwashed with brine
  7. customdried
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-53cc5ea984e74196a5d89134a589e1f0
Source dataset
uspto-grants-2008_12
Patent number
US07468364B2

Reaction notes

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