反应详情

A solution of 5-(4-fluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid methyl-[2-(2,2,2-trifluoro-ethanoylamino)-ethyl]-amide, D4 (443 mg, 1.14 mmol) im methanol/water (30 ml/10 ml) was treated with solid K2CO3 (787 mg, 5.70 mmol) and stirred at room temperature, under argon for 16 h. The methanol was removed in vacuo. The residue was diluted with water and extracted with ethyl acetate (3×). The combined organics were dried (MgSO4) and the solvent removed in vacuo to afford the title compound as a yellow gum (240 mg, 72%).

1. customThe methanol was removed in vacuo
2. additionThe residue was diluted with water
3. extractionextracted with ethyl acetate (3×)
4. dry with materialThe combined organics were dried (MgSO4)
5. customthe solvent removed in vacuo