Nicotinic Acid → 3-Pyridinecarbonyl chloride, hydrochloride (1:1)

HRID 2376778Notes

Reaction equation

HRID 2376778 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.O=P(Cl)(Cl)[Cl:12]>>[ClH:12].[C:1]([Cl:12])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 24813Phosphorus oxychloride

Product 1

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

Procedure

A solution of nicotinic acid (0.50 g, 4.0 mmol) and POCl3 (5 mL) was heated at reflux for 1.5 h and concentrated. The product obtained was directly used in the next reaction.

Workup

  1. temperatureat reflux for 1.5 h
  2. concentrationconcentrated
  3. customThe product obtained
  4. customwas directly used in the next reaction

Sources & evidence

ORD record
ord-5ec44faca2a54f05af600868e378ed4f
Source dataset
uspto-grants-2008_12
Patent number
US07468376B2

Reaction notes

Loading…