HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59710976, compound → 2-[[[4′-(Trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-6-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59710976 | HCID 59710976 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[[[4′-(Trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-6-quinolinecarboxylic acid | HCID 59710973 | — |
Reaction Steps
Intermediate 2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-6-carboxylic acid tert-butyl ester (F-1a1, 9.0 g) was dissolved in 50 mL 4N HCl in dioxane and stirred at room temperature overnight. The solution was concentrated to provide compound F-1a2. The compound was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468378B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-99a8b6cd4a14443b80d08254d14a63e5 |
| Source note | uspto-grants-2008_12 |