HCID 59710976, compound → 2-[[[4′-(Trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-6-quinolinecarboxylic acid

HRID 2376799Notes

Reaction equation

HRID 2376799 reaction equation
C([O:5][C:6]([C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][CH:17]=1)[N:14]=[C:13]([NH:18][C:19]([C:21]1[C:22]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=3)=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:20])[CH:12]=[CH:11]2)=[O:7])(C)(C)C>Cl.O1CCOCC1>[F:36][C:33]([F:34])([F:35])[C:30]1[CH:29]=[CH:28][C:27]([C:22]2[C:21]([C:19]([NH:18][C:13]3[CH:12]=[CH:11][C:10]4[C:15](=[CH:16][CH:17]=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=4)[N:14]=3)=[O:20])=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:32][CH:31]=1

Participants

4

Reactant 1

HCID 59710976HCID 59710976, compound

Product 1

HCID 597109732-[[[4′-(Trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]-6-quinolinecarboxylic acid

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Intermediate 2-[(4′-trifluoromethyl-biphenyl-2-carbonyl)-amino]-quinoline-6-carboxylic acid tert-butyl ester (F-1a1, 9.0 g) was dissolved in 50 mL 4N HCl in dioxane and stirred at room temperature overnight. The solution was concentrated to provide compound F-1a2. The compound was used without further purification.

Workup

  1. concentrationThe solution was concentrated
  2. customto provide compound F-1a2
  3. customThe compound was used without further purification

Sources & evidence

ORD record
ord-99a8b6cd4a14443b80d08254d14a63e5
Source dataset
uspto-grants-2008_12
Patent number
US07468378B2

Reaction notes

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