反应详情

A mixture of 2-amino-quinoline-6-carboxylic acid benzyl ester (15.63 g, 0.0562 moles), 2-propanol (235 mL), water (15.6 mL) and potassium hydroxide (6.3 g, 0.112 moles) was heated to reflux, 80° C. to 85° C., for 2 to 4 hours. The reaction mixture was then cooled to 20° C. to 25° C., vacuum concentrated (volume of 160 mL) and granulated at 20° C. to 25° C. for 8 to 16 hours. The product was isolated by filtration (12.08 g, 0.0534 moles, 95% yield).

1. temperaturewas heated
2. temperatureto reflux, 80° C. to 85° C., for 2 to 4 hours
3. temperatureThe reaction mixture was then cooled to 20° C. to 25° C.
4. concentrationvacuum concentrated (volume of 160 mL)
5. customThe product was isolated by filtration (12.08 g, 0.0534 moles, 95% yield)