2-Bromo-1,4-dimethyl-1H-imidazole → 2-(4-Chloro-3,5-dimethyl-phenyl)-1,4-dimethyl-imidazole

HRID 237681Notes

Reaction equation

HRID 237681 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Br[C:20]1[N:21]([CH3:26])[CH:22]=[C:23]([CH3:25])[N:24]=1>>[Cl:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[N:21]([CH3:26])[CH:22]=[C:23]([CH3:25])[N:24]=2)=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 72048772-Bromo-1,4-dimethyl-1H-imidazoleHCID 532171282-(4-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 866973552-(4-Chloro-3,5-dimethyl-phenyl)-1,4-dimethyl-imidazole

Procedure

The title compound is prepared from 2-chloro-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 2-bromo-1,4-dimethyl-imidazole following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 7): tR=0.82 min; Mass spectrum (ESI+): m/z=235/237 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-59090345900c40afbf00b43cb8603bb5
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

Loading…