HCID 21099407, compound → HCID 21099405, compound

HRID 2376954Notes

Reaction equation

HRID 2376954 reaction equation
[Cl:1]C1C(S(C2C=CC=CC=2)(=O)=O)=CC=C(CCC2C=CC(F)=CC=2F)N=1.[F:27][C:28]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:29]=1[CH2:35][CH2:36][C:37]1[CH:42]=[CH:41][C:40]([S:43]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)(=[O:45])=[O:44])=[CH:39][N+:38]=1[O-]>>[Cl:1][CH:36]([C:37]1[CH:42]=[CH:41][C:40]([S:43]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)(=[O:45])=[O:44])=[CH:39][N:38]=1)[CH2:35][C:29]1[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:28]=1[F:27]

Participants

3

Reactant 2

HCID 21099407HCID 21099407, compoundHCID 21099459HCID 21099459, compound

Product 1

HCID 21099405HCID 21099405, compound

Procedure

2-chloro-6-[2-(2,4-difluorophenyl)ethyl]-3-(phenylsulfonyl)pyridine and the title compound were prepared from 2-[2-(2,4-difluorophenyl)ethyl]-5-(phenylsulfonyl)pyridine 1-oxide according to the method of Example 29 Step 2, separating the products by dry flash column chromatography using toluene-5% ethyl acetate/toluene. m/z (ES+) 394, 396 [MH+].

Workup

  1. customseparating the products
  2. customby dry flash column chromatography

Sources & evidence

ORD record
ord-0f0c84d68c53432987d6740428931f39
Source dataset
uspto-grants-2008_12
Patent number
US07468393B2

Reaction notes

Loading…