HRID237697

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c(-c5c(C)cc(OCC6CCCO6)cc5C)ccc(F)c43)ccc21

HCID86697110

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(OCC2CCCO2)cc(C)c1-c1ccc(F)c2c1CC[C@H]2Oc1ccc2c(c1)OC[C@H]2CC(=O)O

HCID71738994

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

The title compound is prepared from methyl 2-((3S)-6-((1R)-4-(2,6-dimethyl-4-((tetrahydrofuran-2-yl)methoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate following a procedure analogous to that described in example 1. Isopropanol is used instead of methanol. LC (method 1): tR=1.42 min; Mass spectrum (ESI+): m/z=533 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be93185d64924cd0a784ed2dc79f1fb2
来源数据集: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08642585B2
来源说明: uspto-grants-2014_02

反应 SMILES

[CH3:1][C:2]1[CH:7]=[C:6]([O:8][CH2:9][CH:10]2[CH2:14][CH2:13][CH2:12][O:11]2)[CH:5]=[C:4]([CH3:15])[C:3]=1[C:16]1[CH:24]=[CH:23][C:22]([F:25])=[C:21]2[C:17]=1[CH2:18][CH2:19][C@H:20]2[O:26][C:27]1[CH:40]=[CH:39][C:30]2[C@H:31]([CH2:34][C:35]([O:37]C)=[O:36])[CH2:32][O:33][C:29]=2[CH:28]=1>C(O)(C)C>[CH3:15][C:4]1[CH:5]=[C:6]([O:8][CH2:9][CH:10]2[CH2:14][CH2:13][CH2:12][O:11]2)[CH:7]=[C:2]([CH3:1])[C:3]=1[C:16]1[CH:24]=[CH:23][C:22]([F:25])=[C:21]2[C:17]=1[CH2:18][CH2:19][C@H:20]2[O:26][C:27]1[CH:40]=[CH:39][C:30]2[C@H:31]([CH2:34][C:35]([OH:37])=[O:36])[CH2:32][O:33][C:29]=2[CH:28]=1