Hydrochloric Acid → HCID 86697373, compound

Participants

Reaction Steps

1 M aqueous NaOH solution (450 μL) is added to a solution of methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-methoxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate (82 mg) in methanol (2 mL). The mixture is stirred at room temperature for 12 hours. 1 N Hydrochloric acid (450 μL) is added and the residue is purified by HPLC on reversed phase to give the title compound. Yield: 39 mg; LC (method 8): tR=0.97 min; Mass spectrum (ESI+): m/z=549 [M+H]+.

Provenance & Evidence