Hydrochloric Acid → HCID 86697373, compound

HRID 237704Notes

Reaction equation

HRID 237704 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:28]2[C:33]([CH3:34])=[CH:32][C:31]([O:35][CH2:36][C:37]([CH3:42])([CH3:41])[CH2:38][O:39][CH3:40])=[CH:30][C:29]=2[CH3:43])=[C:8]2[C:12]=1[C@H:11]([O:13][C:14]1[CH:27]=[CH:26][C:17]3[C@H:18]([CH2:21][C:22]([O:24]C)=[O:23])[CH2:19][O:20][C:16]=3[CH:15]=1)[CH2:10][CH2:9]2.Cl>CO>[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:28]2[C:33]([CH3:34])=[CH:32][C:31]([O:35][CH2:36][C:37]([CH3:41])([CH3:42])[CH2:38][O:39][CH3:40])=[CH:30][C:29]=2[CH3:43])=[C:8]2[C:12]=1[C@H:11]([O:13][C:14]1[CH:27]=[CH:26][C:17]3[C@H:18]([CH2:21][C:22]([OH:24])=[O:23])[CH2:19][O:20][C:16]=3[CH:15]=1)[CH2:10][CH2:9]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86697131HCID 86697131, compound

Product 1

HCID 86697373HCID 86697373, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 M aqueous NaOH solution (450 μL) is added to a solution of methyl 2-((S)-6-((R)-7-fluoro-4-(4-(3-methoxy-2,2-dimethylpropoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate (82 mg) in methanol (2 mL). The mixture is stirred at room temperature for 12 hours. 1 N Hydrochloric acid (450 μL) is added and the residue is purified by HPLC on reversed phase to give the title compound. Yield: 39 mg; LC (method 8): tR=0.97 min; Mass spectrum (ESI+): m/z=549 [M+H]+.

Workup

  1. customthe residue is purified by HPLC on reversed phase

Sources & evidence

ORD record
ord-192d87290e294da190982b14dc41a4ec
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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