Tetrahydro-4H-pyran-4-ol → HCID 59855845, compound

HRID 2377112Notes

Reaction equation

HRID 2377112 reaction equation
CN([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][N:10]=[C:11]([C:14]([O:16][CH3:17])=[O:15])[CH:12]=2)[N:7]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH:6]=1)C.[O:26]1[CH2:31][CH2:30][CH:29]([OH:32])[CH2:28][CH2:27]1>>[F:25][C:22]1[CH:21]=[CH:20][C:19]([CH2:18][N:7]2[C:8]3=[CH:9][N:10]=[C:11]([C:14]([O:16][CH3:17])=[O:15])[CH:12]=[C:13]3[C:5]([CH2:4][O:32][CH:29]3[CH2:30][CH2:31][O:26][CH2:27][CH2:28]3)=[CH:6]2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 59855831HCID 59855831, compound

Product 1

HCID 59855845HCID 59855845, compound

Procedure

The title compound was prepared as in example 116, step 1, using methyl 3-[(dimethylamino) methyl]-1-(4-fluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylate and tetrahydro-2H-pyran-4-ol.

Sources & evidence

ORD record
ord-8ccb158420eb441b9af5f7c5662e40f9
Source dataset
uspto-grants-2008_12
Patent number
US07468375B2

Reaction notes

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