1-Bromo-2-methylpropane → Methyl 5-tert-butyl-6-isobutoxy-4'-methyl-3-biphenylcarboxylate

HRID 2377204Notes

Reaction equation

HRID 2377204 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:19]([O:21][CH3:22])=[O:20])[CH:8]=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[CH2:23](Br)[CH:24]([CH3:26])[CH3:25]>>[C:1]([C:5]1[CH:6]=[C:7]([C:19]([O:21][CH3:22])=[O:20])[CH:8]=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)[C:10]=1[O:11][CH2:23][CH:24]([CH3:26])[CH3:25])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 12084822Methyl 5-tert-butyl-6-hydroxy-4'-methyl-3-biphenylcarboxylate

Product 1

HCID 12084823Methyl 5-tert-butyl-6-isobutoxy-4'-methyl-3-biphenylcarboxylateYield 95%

Procedure

In a manner similar to that of Example 1c, by reacting 1.57 g (5.3 mmol) of methyl 5-tert-butyl-6-hydroxy-4′-methyl-3-biphenylcarboxylate with 1.14 mL (10.5 mmol) of isobutyl bromide. A yellow oil is obtained (m=1.8 g; yield=95%).

Workup

  1. customA yellow oil is obtained (m=1.8 g; yield=95%)

Sources & evidence

ORD record
ord-ea73c32ded2745508f89479ed511f767
Source dataset
uspto-grants-2008_12
Patent number
US07468457B2

Reaction notes

Loading…