HCID 86598702, compound → HCID 86598703, compound

HRID 2377211Notes

Reaction equation

HRID 2377211 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:19]([CH3:22])([CH3:21])[CH2:18][CH2:17][C:16]([CH3:24])([CH3:23])[C:15]=3[CH:14]=[C:13]([CH:25]=[O:26])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:27]([Mg]Br)#[CH:28]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:20]3[C:19]([CH3:22])([CH3:21])[CH2:18][CH2:17][C:16]([CH3:24])([CH3:23])[C:15]=3[CH:14]=[C:13]([CH:25]([OH:26])[C:27]#[CH:28])[CH:12]=2)=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 86598702HCID 86598702, compoundHCID 178418486HCID 178418486, compound

Product 1

HCID 86598703HCID 86598703, compoundYield 80%

Procedure

In a manner similar to that of Example 1f, by reacting 350 mg (1 mmol) of 4-(4-tert-butylphenyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenecarbaldehyde with 2.6 mL (1.3 mmol) of 0.5 N ethynylmagnesium bromide solution. White crystals are obtained (m=300 mg; yield=80%).

Workup

  1. customWhite crystals are obtained (m=300 mg; yield=80%)

Sources & evidence

ORD record
ord-c603ffd45db94ce8b22480ddfda5e0f7
Source dataset
uspto-grants-2008_12
Patent number
US07468457B2

Reaction notes

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