Benzimidazole → 1-prop-2-ynylbenzimidazole

HRID 2377283Notes

Reaction equation

HRID 2377283 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[H-].[Na+].[CH3:12][C:13](C)([O-])[CH3:14].[K+]>>[CH2:14]([N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1)[C:13]#[CH:12]

Participants

4

Reactant 3

HCID 5798BenzimidazoleHCID 24758Sodium hydrideHCID 23665647Potassium tert-butoxide

Product 1

HCID 20483131-prop-2-ynylbenzimidazole

Procedure

The procedure for Example 648 was used, substituting pyrrolidin-2-one for 1H-benzimidazole and sodium hydride for potassium tert-butoxide to provide Example 649. MS (ESI): m/z 124 (M+H)+.

Workup

  1. customto provide Example 649

Sources & evidence

ORD record
ord-471ec16855de410aae3805b370ee6337
Source dataset
uspto-grants-2008_12
Patent number
US07468371B2

Reaction notes

Loading…