HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpiperazine → 6-(4-Methyl-piperazin-1-yl)-benzofuran-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 6-Fluoro-2,3-dihydro-1-benzofuran-3-one | HCID 18354312 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 6-(4-Methyl-piperazin-1-yl)-benzofuran-3-one | HCID 69202678 | — |
Reaction Steps
A mixture of Example 1109B (0.152 g) and 1-methylpiperazine (0.22 g) in DMSO (1 ml) was heated at 150 C for 30 min, allowed to cool to r.t. (room temperature) then partitioned between water and EtOAc. Organics were dried (Na2SO4), concentrated and purified via silica gel chromatography eluting with 5% MeOH-CH2Cl2 to give the title compound. MS ESI(+)m/e 233.0(M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07468371B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-fb220d5d5cb74607aea7e0751cb9882a |
| Source note | uspto-grants-2008_12 |