反应详情

A mixture of Example 1109B (0.152 g) and 1-methylpiperazine (0.22 g) in DMSO (1 ml) was heated at 150 C for 30 min, allowed to cool to r.t. (room temperature) then partitioned between water and EtOAc. Organics were dried (Na2SO4), concentrated and purified via silica gel chromatography eluting with 5% MeOH-CH2Cl2 to give the title compound. MS ESI(+)m/e 233.0(M+H)+.

1. customthen partitioned between water and EtOAc
2. dry with materialOrganics were dried (Na2SO4)
3. concentrationconcentrated
4. custompurified via silica gel chromatography
5. washeluting with 5% MeOH-CH2Cl2