Ethyl formate → HCID 21107219, compound

HRID 2377318Notes

Reaction equation

HRID 2377318 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:12][NH:13][CH:14]3[CH2:16][CH2:15]3)[CH:11]=1)[O:8][C:7]([CH3:18])([CH3:17])[CH2:6][C:5]2([CH3:20])[CH3:19].[CH:21](OCC)=[O:22]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([CH2:12][N:13]([CH:14]3[CH2:15][CH2:16]3)[CH:21]=[O:22])[CH:11]=1)[O:8][C:7]([CH3:18])([CH3:17])[CH2:6][C:5]2([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 211072186-Bromo-8-[(cyclopropyl-amino)-methyl]-2,2,4,4-tetramethyl-chroman2×

Product 1

HCID 21107219HCID 21107219, compoundYield 100%

Procedure

A solution of 6-bromo-8-[(cyclopropyl-amino)-methyl]-2,2,4,4-tetramethyl-chroman (Intermediate 7, 1.4 g, 4.14 mmol) in ethyl formate was refluxed for 6 h. The solvent was distilled off in vacuo to afford the title compound as a clear oil (1.56 g, 100%).

Workup

  1. distillationThe solvent was distilled off in vacuo

Sources & evidence

ORD record
ord-35baaf34d4cf44faabc66153f73f75c0
Source dataset
uspto-grants-2008_12
Patent number
US07468391B2

Reaction notes

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